Dataset Information

Effect of pulmonary vein cryoballoon ablation in dogs with coolant-nitrogen.

ABSTRACT:

Background

The Arctic Front Advance System with nitrous oxide (N₂O) refrigerant is the leading system for the cryoballoon ablation of atrial fibrillation (AF). A novel cryoablation system with nitrogen (N₂) refrigerant was developed with technical improvements seeking to improve outcomes. Cryoballoon ablation with the N₂ refrigerant may be effective and safe for pulmonary vein isolation (PVI).

Methods

In total, 16 dogs were included in the study, of which 13 underwent PVI procedures, and 3 served as baseline controls. Cryoballoons (Cryofocus, Int.) with N₂ refrigerant were used for the study group, which comprised 8 dogs, and second-generation cryoballoons with N₂O refrigerant (Arctic Front Advance; Medtronic, Inc., MN, USA) were used for the control group, which comprised 5 dogs. Three dogs of the study group and 2 dogs of the control group were euthanized on the same day post-ablation. The other 8 dogs of the two groups were euthanized 1 month post-ablation. The removed organs were examined for gross anatomy and histological review.

Results

The average ablation times for each pulmonary vein (PV) in the study group were less than those in the control group (1.1±0.3 vs. 2.0±0.8; P=0.006). The procedure duration of the study group was shorter than that of the control group (379±46 vs. 592±162 s; P=0.013). And the time to isolation (TTI) was similar between the groups. The PVI rate of the single-ablation was higher in the study group than the control group (92.9% vs. 60.0%; P=0.05). In relation to safety, there was no evidence of thrombus, esophageal injury, or pericardial tamponade in any of the dogs. Only 1 incidence of self-limited phrenic nerve paralysis (PNP) was observed in the control group.

Conclusions

The novel cryoablation system with the N₂ refrigerant had better efficacy than and similar safety to that of the system (Medtronic, Int.) with the N₂O refrigerant.

SUBMITTER: Xie Y

PROVIDER: S-EPMC9186217 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature

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Publications

Effect of pulmonary vein cryoballoon ablation in dogs with coolant-nitrogen.

Xie Yun Y Guo Rong R Yan Meiyu M Zhao Tingting T Xu Yawei Y Zhao Dongdong D

Journal of thoracic disease 20220501 5

<h4>Background</h4>The Arctic Front Advance System with nitrous oxide (N<sub>2</sub>O) refrigerant is the leading system for the cryoballoon ablation of atrial fibrillation (AF). A novel cryoablation system with nitrogen (N<sub>2</sub>) refrigerant was developed with technical improvements seeking to improve outcomes. Cryoballoon ablation with the N<sub>2</sub> refrigerant may be effective and safe for pulmonary vein isolation (PVI).<h4>Methods</h4>In total, 16 dogs were included in the study, o ...[more]

PMID: 35693593

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Project description:ObjectiveCurrently radiofrequency and cryoballoon ablations are the two standard ablation systems used for catheter ablation of atrial fibrillation; however, there is no universal consensus on which ablation is the optimal choice. We therefore sought to undertake a meta-analysis with special emphases on comparing the efficacy and safety between cryoballoon and radiofrequency ablations by synthesizing published clinical trials.Methods and resultsArticles were identified by searching the MEDLINE and EMBASE databases before September 2013, by reviewing the bibliographies of eligible reports, and by consulting with experts in this field. Data were extracted independently and in duplicate. There were respectively 469 and 635 patients referred for cryoballoon and radiofrequency ablations from 14 qualified clinical trials. Overall analyses indicated that cryoballoon ablation significantly reduced fluoroscopic time and total procedure time by a weighted mean of 14.13 (95% confidence interval [95% CI]: 2.82 to 25.45; P = 0.014) minutes and 29.65 (95% CI: 8.54 to 50.77; P = 0.006) minutes compared with radiofrequency ablation, respectively, whereas ablation time in cryoballoon ablation was nonsignificantly elongated by a weighted mean of 11.66 (95% CI: -10.71 to 34.04; P = 0.307) minutes. Patients referred for cryoballoon ablation had a high yet nonsignificant success rate of catheter ablation compared with cryoballoon ablation (odds ratio; 95% CI; P: 1.34; 0.53 to 3.36; 0.538), and cryoballoon ablation was also found to be associated with the relatively low risk of having recurrent atrial fibrillation (0.75; 0.3 to 1.88; 0.538) and major complications (0.46; 0.11 to 1.83; 0.269). There was strong evidence of heterogeneity and low probability of publication bias.ConclusionOur findings demonstrate greater improvement in fluoroscopic time and total procedure duration for atrial fibrillation patients referred for cryoballoon ablation than those for radiofrequency ablation.

Dataset Information

Effect of pulmonary vein cryoballoon ablation in dogs with coolant-nitrogen.

Background

Methods

Results

Conclusions

Publications

Effect of pulmonary vein cryoballoon ablation in dogs with coolant-nitrogen.

Similar Datasets

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