Ontology highlight
ABSTRACT:
SUBMITTER: Heard A
PROVIDER: S-EPMC9188573 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
Heard Amanda A Landmann Jack H JH Hansen Ava R AR Papadopolou Alkmini A Hsu Yu-Sung YS Selli Mehmet Emrah ME Warrington John M JM Lattin John J Chang Jufang J Ha Helen H Haug-Kroeper Martina M Doray Balraj B Gill Saar S Ruella Marco M Hayer Katharina E KE Weitzman Matthew D MD Green Abby M AM Fluhrer Regina R Singh Nathan N
Nature communications 20220611 1
While chimeric antigen receptor (CAR) T cells targeting CD19 can cure a subset of patients with B cell malignancies, most patients treated will not achieve durable remission. Identification of the mechanisms leading to failure is essential to broadening the efficacy of this promising platform. Several studies have demonstrated that disruption of CD19 genes and transcripts can lead to disease relapse after initial response; however, few other tumor-intrinsic drivers of CAR T cell failure have bee ...[more]