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Mechanistic insights into fungal mitochondrial outer membrane protein biogenesis.

ABSTRACT: The majority of mitochondrial proteins are nuclear-encoded and need to be transported into the mitochondria, including the proteins in the outer mitochondrial membrane. For β-barrel proteins, the preproteins are initially recognized and imported by the TOM complex, then shuttled to the SAM complex via small Tim proteins. For ⍺-helical proteins, some preproteins are recognized by the TOM complex and imported into the membrane by the MIM complex. In recent years multiple structures of the TOM complex and the SAM complex have been reported, increasing our understanding of the mechanism of protein biogenesis in the outer mitochondrial membrane.

SUBMITTER: Diederichs KA

PROVIDER: S-EPMC9189057 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature

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Mechanistic insights into fungal mitochondrial outer membrane protein biogenesis.

Diederichs Kathryn A KA Pitt Ashley S AS Varughese Joyce T JT Hackel Taylor N TN Buchanan Susan K SK Shaw Porsha L PL

Current opinion in structural biology 20220430

The majority of mitochondrial proteins are nuclear-encoded and need to be transported into the mitochondria, including the proteins in the outer mitochondrial membrane. For β-barrel proteins, the preproteins are initially recognized and imported by the TOM complex, then shuttled to the SAM complex via small Tim proteins. For ⍺-helical proteins, some preproteins are recognized by the TOM complex and imported into the membrane by the MIM complex. In recent years multiple structures of the TOM comp ...[more]

PMID: 35504104

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