Ontology highlight
ABSTRACT:
SUBMITTER: Naik HC
PROVIDER: S-EPMC9189126 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
Naik Hemant Chandru HC Hari Kishore K Chandel Deepshikha D Jolly Mohit Kumar MK Gayen Srimonta S
iScience 20220525 6
In mammals, transcriptional inactivation of one X chromosome in female compensates for the dosage of X-linked gene expression between the sexes. Additionally, it is believed that the upregulation of active X chromosome in male and female balances the dosage of X-linked gene expression relative to autosomal genes, as proposed by Ohno. However, the existence of X chromosome upregulation (XCU) remains controversial. Here, we have profiled gene-wise dynamics of XCU in pre-gastrulation mouse embryos ...[more]