Behavioral and neural responses during fear conditioning and extinction in a large transdiagnostic sample.

ABSTRACT:

Background

Dysregulation of fear learning has been associated with psychiatric disorders that have altered positive and negative valence domain function. While amygdala-insula-prefrontal circuitry is considered important for fear learning, there have been inconsistencies in neural findings in healthy and clinical human samples. This study aimed to delineate the neural substrates and behavioral responses during fear learning in a large, transdiagnostic sample with predominantly depressive and/or anxious dysfunction.

Methods

Two-hundred and eighty-two individuals (52 healthy participants; 230 participants with depression and/or anxiety-related problems) from the Tulsa 1000 study, an ongoing, naturalistic longitudinal study based on a dimensional psychopathological framework, c

SUBMITTER: Kirlic N 

PROVIDER: S-EPMC9189200 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature