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Case Report: A Severe Paediatric Presentation of COVID-19 in APDS2 Immunodeficiency.

ABSTRACT: Critical respiratory manifestations of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) are rare in children, and little is known about how immunocompromised children respond to the infection. We report a case of a 4-year-old boy with activated PI3K delta syndrome type 2 (APDS2) with a protracted and severe COVID-19 course with both inflammatory and acute respiratory features. He was treated with remdesivir, nitazoxanide, high-dose corticosteroids, and tocilizumab and made a full recovery. We propose that remdesivir may be used in combination with nitazoxanide to improve viral clearance and reduce the chance of resistance in treating acute SARS-CoV-2 infection.

SUBMITTER: Sanchez Clemente N

PROVIDER: S-EPMC9190774 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Case Report: A Severe Paediatric Presentation of COVID-19 in APDS2 Immunodeficiency.

Sanchez Clemente Nuria N Penner Justin J Breuer Judith J Ip Winnie W Booth Claire C

Frontiers in immunology 20220530

Critical respiratory manifestations of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) are rare in children, and little is known about how immunocompromised children respond to the infection. We report a case of a 4-year-old boy with activated PI3K delta syndrome type 2 (APDS2) with a protracted and severe COVID-19 course with both inflammatory and acute respiratory features. He was treated with remdesivir, nitazoxanide, high-dose corticosteroids, and tocilizumab and made a full rec ...[more]

PMID: 35707532

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