New synthesis of a late-stage tetracyclic key intermediate of lumateperone.
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ABSTRACT: New approaches have been tested for the synthesis of lumateperone intermediates. As a result of these efforts, a novel synthesis of the late-stage tetracyclic key intermediate of lumateperone starting from the commercially available quinoxaline is described. The tetracyclic skeleton was constructed by the reaction of 1-trifluoroacetyl-4-aminoquinoxaline with ethyl 4-oxopiperidine-1-carboxylate in a Fischer indole synthesis. The inexpensive starting material, the efficient synthetic steps, and the avoidance of the borane-based reduction step provide a reasonable potential for scalability.
SUBMITTER: Milen M
PROVIDER: S-EPMC9194496 | biostudies-literature |
REPOSITORIES: biostudies-literature
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