Mortality Among Patients Undergoing Blood Transfusion in Relation to Donor Sex and Parity: A Natural Experiment.

ABSTRACT:

Importance

Prior evidence suggests that plasma and platelet transfusions from female and parous donors are associated with adverse clinical outcomes, which has led to the predominant use of male donors for plasma and platelets in many countries. However, studies on red blood cell transfusions have been conflicting.

Objective

To determine whether blood donor sex and parity affect mortality of patients undergoing transfusion with red blood cells.

Design, setting, and participants

This cohort study used nationwide blood bank and health register data in Sweden and involved a natural experiment created by donor sex and parity being concealed and randomly allocated. Patients were included if they were 18 to 90 years old, did not have a history of blood transfusion, and rece

SUBMITTER: Zhao J 

PROVIDER: S-EPMC9194724 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature