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Selective visuoconstructional impairment following mild COVID-19 with inflammatory and neuroimaging correlation findings.

ABSTRACT: People recovered from COVID-19 may still present complications including respiratory and neurological sequelae. In other viral infections, cognitive impairment occurs due to brain damage or dysfunction caused by vascular lesions and inflammatory processes. Persistent cognitive impairment compromises daily activities and psychosocial adaptation. Some level of neurological and psychiatric consequences were expected and described in severe cases of COVID-19. However, it is debatable whether neuropsychiatric complications are related to COVID-19 or to unfoldings from a severe infection. Nevertheless, the majority of cases recorded worldwide were mild to moderate self-limited illness in non-hospitalized people. Thus, it is important to understand what are the implications of mild COVID-19, which is the largest and understudied pool of COVID-19 cases. We aimed to investigate adults at least four months after recovering from mild COVID-19, which were assessed by neuropsychological, ocular and neurological tests, immune markers assay, and by structural MRI and ¹⁸FDG-PET neuroimaging to shed light on putative brain changes and clinical correlations. In approximately one-quarter of mild-COVID-19 individuals, we detected a specific visuoconstructive deficit, which was associated with changes in molecular and structural brain imaging, and correlated with upregulation of peripheral immune markers. Our findings provide evidence of neuroinflammatory burden causing cognitive deficit, in an already large and growing fraction of the world population. While living with a multitude of mild COVID-19 cases, action is required for a more comprehensive assessment and follow-up of the cognitive impairment, allowing to better understand symptom persistence and the necessity of rehabilitation of the affected individuals.

SUBMITTER: de Paula JJ

PROVIDER: S-EPMC9196149 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature

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Selective visuoconstructional impairment following mild COVID-19 with inflammatory and neuroimaging correlation findings.

de Paula Jonas Jardim JJ Paiva Rachel E R P RERP Souza-Silva Nathália Gualberto NG Rosa Daniela Valadão DV Duran Fabio Luis de Souza FLS Coimbra Roney Santos RS Costa Danielle de Souza DS Dutenhefner Pedro Robles PR Oliveira Henrique Soares Dutra HSD Camargos Sarah Teixeira ST Vasconcelos Herika Martins Mendes HMM de Oliveira Carvalho Nara N da Silva Juliana Batista JB Silveira Marina Bicalho MB Malamut Carlos C Oliveira Derick Matheus DM Molinari Luiz Carlos LC de Oliveira Danilo Bretas DB Januário José Nélio JN Silva Luciana Costa LC De Marco Luiz Armando LA Queiroz Dulciene Maria de Magalhaes DMM Meira Wagner W Busatto Geraldo G Miranda Débora Marques DM Romano-Silva Marco Aurélio MA

Molecular psychiatry 20220614 2

People recovered from COVID-19 may still present complications including respiratory and neurological sequelae. In other viral infections, cognitive impairment occurs due to brain damage or dysfunction caused by vascular lesions and inflammatory processes. Persistent cognitive impairment compromises daily activities and psychosocial adaptation. Some level of neurological and psychiatric consequences were expected and described in severe cases of COVID-19. However, it is debatable whether neurops ...[more]

PMID: 35701598

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Dataset Information

Selective visuoconstructional impairment following mild COVID-19 with inflammatory and neuroimaging correlation findings.

Publications

Selective visuoconstructional impairment following mild COVID-19 with inflammatory and neuroimaging correlation findings.

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