Association of proton pump inhibitor use and significant hyponatremia-a US population-based case-control study.

ABSTRACT: Hyponatremia is the most common electrolyte abnormality encountered in clinical practice. Several medications are associated with hyponatremia. Proton pump inhibitors were reported to cause hyponatremia in one large Swedish population-based study and small observational studies or case reports. This article presents the results of a single-center retrospective case-control study based on a US patient population that examined the association between the use of proton pump inhibitors and significant hyponatremia. Cases were 792 hospitalized patients with hyponatremia, extracted from 473,000 patient encounters over 6 years, and matched controls were 774 hospitalized patients with normal serum sodium levels whose risk factors for hyponatremia were comparable to those of the study cases. The re

SUBMITTER: El-Alali E 

PROVIDER: S-EPMC9196735 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature