Ontology highlight
ABSTRACT:
SUBMITTER: Olmsted ZT
PROVIDER: S-EPMC9198845 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
Olmsted Zachary T ZT Paluh Janet L JL
iScience 20220530 6
Multi-lineage development from gastruloids is enabling unprecedented opportunities to model and study human embryonic processes and is expected to accelerate <i>ex vivo</i> strategies in organ development. Reproducing human cardiogenesis with neurogenesis in a multi-lineage context remains challenging, requiring spatiotemporal input of paracrine and mechanical cues. Here we extend elongating multi-lineage organized (EMLO) gastruloids to include cardiogenesis (EMLOC) and describe interconnected n ...[more]