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De novo designed peptides form a highly catalytic ordered nanoarchitecture on a graphite surface.

ABSTRACT: Here we demonstrate that short peptides, de novo designed from first principles, self-assemble on the surface of graphite to produce a highly robust and catalytic nanoarchitecture, which promotes peroxidation reactions with activities that rival those of natural enzymes in both single and multi-substrate reactions. These designable peptides recapitulate the symmetry of the underlying graphite surface and act as molecular scaffolds to immobilize hemin molecules on the electrode in a hierarchical self-assembly manner. The highly ordered and uniform hybrid graphite-peptide-hemin nanoarchitecture shows the highest faradaic efficiency of any hybrid electrode reported. Given the explosive growth of the types of chemical reactions promoted by self-assembled peptide materials, this new approach to creating complex electrocatalytic assemblies will yield highly efficient and practically applicable electrocatalysts.

SUBMITTER: Luo W

PROVIDER: S-EPMC9202597 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Cell-Free Expression of <i>De Novo</i> Designed Peptides That Form β-Barrel Nanopores.

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| S-EPMC6151875 | biostudies-literature

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| S-EPMC3502156 | biostudies-literature

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