Repurposing benzbromarone as antifolate to develop novel antifungal therapy for Candida albicans.

ABSTRACT: Fungal infections in humans are responsible for mild to severe infections resulting in systemic effects that cause a large amount of mortality. Invasive fungal infections are having similar symptomatic effects to those of COVID-19. The COVID-19 patients are immunocompromised in nature and have a high probability of developing severe fungal infections, resulting in the development of further complications. The existing antifungal therapy has associated problems related to the development of drug resistance, being sub-potent in nature, and the presence of undesirable toxic effects. The fungal dihydrofolate reductase is an essential enzyme involved in the absorption of dietary folic acid and its conversion into tetrahydrofolate, which is a coenzyme required for the biosynthesis of the fungal

SUBMITTER: Mujwar S 

PROVIDER: S-EPMC9206073 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature