Ontology highlight
ABSTRACT:
SUBMITTER: Shi W
PROVIDER: S-EPMC9207357 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
Shi Wenjing W Zhang Fang F Chen Xiaozheng X Wang Shuyun S Zhang Haiqin H Yang Zijiang Z Wang Guiying G Zheng Yan Y Han Yali Y Sun Yuping Y Gao Aiqin A
Cancer science 20220428 6
Infiltration of immunosuppressive cells in the tumor microenvironment (TME) induced colorectal cancer (CRC) progression and its resistance to immunotherapy. Identification of tumor-specific factors to modulate inhibitory immunocyte infiltration would provide alternative and novel targets for CRC immunotherapy. Immunoglobulin-like transcript (ILT) 5 is a negative regulator of myeloid cell activation. However, its expression and functional role in solid tumors is still unknown. Using human CRC tis ...[more]