Ontology highlight
ABSTRACT:
SUBMITTER: Zhang S
PROVIDER: S-EPMC9207374 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
Zhang Shuai S He Yunlong Y Xuan Qijia Q Ling Xiaodong X Men Kaiya K Zhao Xu X Xue Dinglong D Li Ling L Zhang Yingying Y
Cancer science 20220401 6
Non-small-cell lung cancer (NSCLC) accounts for approximately 85% of all lung cancer cases and has the highest mortality rate among all solid tumors. It is characterized by early metastasis, and investigations of the molecular mechanisms underlying the progression and metastasis of NSCLC are urgently needed for the development of therapeutic targets. Here, we report that the transmembrane protein TMEM139 is significantly downregulated in NSCLC and that reduced expression of TMEM139 is correlated ...[more]