Unknown

Dataset Information

0

TMEM139 prevents NSCLC metastasis by inhibiting lysosomal degradation of E-cadherin.


ABSTRACT: Non-small-cell lung cancer (NSCLC) accounts for approximately 85% of all lung cancer cases and has the highest mortality rate among all solid tumors. It is characterized by early metastasis, and investigations of the molecular mechanisms underlying the progression and metastasis of NSCLC are urgently needed for the development of therapeutic targets. Here, we report that the transmembrane protein TMEM139 is significantly downregulated in NSCLC and that reduced expression of TMEM139 is correlated with a poor prognosis in NSCLC patients. Mechanistically, we found that TMEM139 directly interacts with E-cadherin at the plasma membrane and at focal adhesion sites. Moreover, TMEM139 can prevent the lysosomal degradation of E-cadherin, which inhibits epithelial-mesenchymal transition, migration and invasion of NSCLC cells both in vitro and in vivo. Our study not only expands our understanding of NSCLC metastasis but also provides a foundation to develop novel therapeutic strategies.

SUBMITTER: Zhang S 

PROVIDER: S-EPMC9207374 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature

altmetric image

Publications

TMEM139 prevents NSCLC metastasis by inhibiting lysosomal degradation of E-cadherin.

Zhang Shuai S   He Yunlong Y   Xuan Qijia Q   Ling Xiaodong X   Men Kaiya K   Zhao Xu X   Xue Dinglong D   Li Ling L   Zhang Yingying Y  

Cancer science 20220401 6


Non-small-cell lung cancer (NSCLC) accounts for approximately 85% of all lung cancer cases and has the highest mortality rate among all solid tumors. It is characterized by early metastasis, and investigations of the molecular mechanisms underlying the progression and metastasis of NSCLC are urgently needed for the development of therapeutic targets. Here, we report that the transmembrane protein TMEM139 is significantly downregulated in NSCLC and that reduced expression of TMEM139 is correlated  ...[more]

Similar Datasets

| S-EPMC8909100 | biostudies-literature
| S-EPMC10066282 | biostudies-literature
| S-EPMC9288479 | biostudies-literature
2025-02-13 | GSE272492 | GEO
| S-EPMC9091366 | biostudies-literature
| S-EPMC7498585 | biostudies-literature
| S-EPMC10541412 | biostudies-literature
| S-EPMC8094600 | biostudies-literature
| S-EPMC10987140 | biostudies-literature
| S-EPMC10082367 | biostudies-literature