Unknown

Dataset Information

0

Targeted drug release system based on pH-responsive PAA-POSS nanoparticles.


ABSTRACT: An amphipathic PAA-POSS@DOX drug delivery system that responds sensitively to pH changes in the cancer microenvironment has been developed using a nanoparticle based on inorganic polyhedral oligomeric silsesquioxane (POSS). POSS was introduced to the carboxylic acid group of polyacrylic acid to which doxorubicin anticancer drug was loaded to prepare 480 ± 192 nm self-assembled nanoparticles. PAA-POSS had a high loading efficiency of over 75% and doxorubicin was quickly released to the target area responding sensitively to weakly acidic conditions. The possibility of employing PAA-POSS as a targeted drug delivery system has been confirmed by observing the death of cells of the MDA-MB-231 breast cancer line.

SUBMITTER: Kim WJ 

PROVIDER: S-EPMC9214607 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC9049203 | biostudies-literature
| S-EPMC9571272 | biostudies-literature
| S-EPMC4431183 | biostudies-literature
| S-EPMC8575987 | biostudies-literature
| S-EPMC5618340 | biostudies-literature
| S-EPMC7294702 | biostudies-literature
| S-EPMC7440925 | biostudies-literature
| S-EPMC6160908 | biostudies-other
| S-EPMC3808531 | biostudies-literature
| S-EPMC7116326 | biostudies-literature