Germline genetic host factors as predictive biomarkers in immuno-oncology.
Ontology highlight
ABSTRACT:
SUBMITTER: Chat V
PROVIDER: S-EPMC9216465 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Publications
Germline genetic host factors as predictive biomarkers in immuno-oncology.
Chat Vylyny V Ferguson Robert R Kirchhoff Tomas T
Immuno-oncology technology 20190905
In immuno-oncology (IO), the baseline host factors attract significant clinical interest as promising predictive biomarker candidates. Growing evidence from experimental or population-based studies suggests that the host genetic factors contribute to the immunological status of a patient as it plays out at the multiple rate-limiting steps of the cancer immunity cycle. Recent observations suggest that germline genetics may be associated with tumor microenvironment phenotypes, autoimmune toxicitie ...[more]
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