Neurotransmitters of sleep and wakefulness in flatworms.

ABSTRACT:

Study objectives

Sleep is a prominent behavioral and biochemical state observed in all animals studied, including platyhelminth flatworms. Investigations into the biochemical mechanisms associated with sleep-and wakefulness-are important for understanding how these states are regulated and how that regulation changed with the evolution of new types of animals. Unfortunately, beyond a handful of vertebrates, such studies on invertebrates are rare.

Methods

We investigated the effect of seven neurotransmitters, and one pharmacological compound, that modulate either sleep or wakefulness in mammals, on flatworms (Girardia tigrina). Flatworms were exposed via ingestion and diffusion to four neurotransmitters that promote wakefulness in vertebrates (acetylcholine, dopamine, glutama

SUBMITTER: Omond SET 

PROVIDER: S-EPMC9216492 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature