Population genomic analyses reveal evidence for limited recombination in the superbug Candida auris in nature.

ABSTRACT: Candida auris is a recently emerged, multidrug-resistant pathogenic yeast capable of causing a diversity of human infections worldwide. Genetic analyses based on whole-genome sequences have clustered strains in this species into five divergent clades, with each clade containing limited genetic variation and one of two mating types, MTL a or MTL α. The patterns of genetic variations suggest simultaneous emergence and clonal expansion of multiple clades of this pathogen across the world. At present, it is unclear whether recombination has played any role during the evolution of C. auris. In this study, we analyzed patterns of associations among single nucleotide polymorphisms in both the nuclear and the mitochondrial genomes of 1,285 strains to inves

SUBMITTER: Wang Y 

PROVIDER: S-EPMC9218166 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature