Childhood antibiotics as a risk factor for Crohn's disease: The ENIGMA International Cohort Study.

ABSTRACT:

Background and aim

Environmental factors play a key role in development of Crohn's disease (CD), thought to be mediated by changes in the gut microbiota. We aimed to delineate the potential contribution of antibiotic exposure to subsequent development of CD, across diverse geographical populations.

Methods

This case-control study in Australia and three cities in China (Hong Kong, Guangzhou, and Kunming) included four groups: patients with CD, at-risk individuals including non-affected first-degree relatives (FDRs) and household members of CD patients (HM), and unrelated healthy controls (HCs). Environmental risk factors, including childhood antibiotic use and 13 other categories, were assessed using a self-developed questionnaire. Logistic regression and conditional logistic

SUBMITTER: Mak JWY 

PROVIDER: S-EPMC9218523 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature