The influence of a manipulation of threat on experimentally-induced secondary hyperalgesia.

ABSTRACT: Pain is thought to be influenced by the threat value of the particular context in which it occurs. However, the mechanisms by which a threat achieves this influence on pain are unclear. Here, we explore how threat influences experimentally-induced secondary hyperalgesia, which is thought to be a manifestation of central sensitization. We developed an experimental study to investigate the effect of a manipulation of threat on experimentally-induced secondary hyperalgesia in 26 healthy human adults (16 identifying as female; 10 as male). We induced secondary hyperalgesia at both forearms using high-frequency electrical stimulation. Prior to the induction, we used a previously successful method to manipulate threat of tissue damage at one forearm (threat site). The effect of the threat manipu

SUBMITTER: Bedwell GJ 

PROVIDER: S-EPMC9220919 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature