Dataset Information

Inference for partially observed competing risks model for Kumaraswamy distribution under generalized progressive hybrid censoring.

ABSTRACT: In this paper, inference for a competing risks model is studied when latent failure times follow Kumaraswamy distribution and causes of failure are partially observed. Under generalized progressive hybrid censoring, existence and uniqueness of maximum likelihood estimators of model parameters are established. The confidence intervals are obtained by using asymptotic distribution theory. We further compute Bayes estimators along with credible intervals. In addition, inference is also discussed when there is order restricted shape parameters. The performance of all estimates is investigated using Monte-Carlo simulations. Finally, analysis of a real data set is presented for illustration purposes.

SUBMITTER: Mahto AK

PROVIDER: S-EPMC9225323 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Inference for partially observed competing risks model for Kumaraswamy distribution under generalized progressive hybrid censoring.

Mahto Amulya Kumar AK Lodhi Chandrakant C Tripathi Yogesh Mani YM Wang Liang L

Journal of applied statistics 20210223 8

In this paper, inference for a competing risks model is studied when latent failure times follow Kumaraswamy distribution and causes of failure are partially observed. Under generalized progressive hybrid censoring, existence and uniqueness of maximum likelihood estimators of model parameters are established. The confidence intervals are obtained by using asymptotic distribution theory. We further compute Bayes estimators along with credible intervals. In addition, inference is also discussed wh ...[more]

PMID: 35757591

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Project description:Outcome misclassification occurs frequently in binary-outcome studies and can result in biased estimation of quantities such as the incidence, prevalence, cause-specific hazards, cumulative incidence functions, and so forth. A number of remedies have been proposed to address the potential misclassification of the outcomes in such data. The majority of these remedies lie in the estimation of misclassification probabilities, which are in turn used to adjust analyses for outcome misclassification. A number of authors advocate using a gold-standard procedure on a sample internal to the study to learn about the extent of the misclassification. With this type of internal validation, the problem of quantifying the misclassification also becomes a missing data problem as, by design, the true outcomes are only ascertained on a subset of the entire study sample. Although, the process of estimating misclassification probabilities appears simple conceptually, the estimation methods proposed so far have several methodological and practical shortcomings. Most methods rely on missing outcome data to be missing completely at random (MCAR), a rather stringent assumption which is unlikely to hold in practice. Some of the existing methods also tend to be computationally-intensive. To address these issues, we propose a computationally-efficient, easy-to-implement, pseudo-likelihood estimator of the misclassification probabilities under a missing at random (MAR) assumption, in studies with an available internal-validation sample. We present the estimator through the lens of studies with competing-risks outcomes, though the estimator extends beyond this setting. We describe the consistency and asymptotic distributional properties of the resulting estimator, and derive a closed-form estimator of its variance. The finite-sample performance of this estimator is evaluated via simulations. Using data from a real-world study with competing-risks outcomes, we illustrate how the proposed method can be used to estimate misclassification probabilities. We also show how the estimated misclassification probabilities can be used in an external study to adjust for possible misclassification bias when modeling cumulative incidence functions.

Dataset Information

Inference for partially observed competing risks model for Kumaraswamy distribution under generalized progressive hybrid censoring.

Publications

Inference for partially observed competing risks model for Kumaraswamy distribution under generalized progressive hybrid censoring.

Similar Datasets

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