Ontology highlight
ABSTRACT:
SUBMITTER: Budryn G
PROVIDER: S-EPMC9227119 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
Budryn Grażyna G Majak Iwona I Grzelczyk Joanna J Szwajgier Dominik D Rodríguez-Martínez Alejandro A Pérez-Sánchez Horacio H
Nutrients 20220615 12
One of the symptoms of Alzheimer's disease (AD) is low acetylcholine level due to high acetylcholinesterase (AChE) activity. For this reason, AChE inhibitors are used in the treatment of AD, the prolonged use of which may cause a cholinergic crisis. There is a need to search for safe natural AChE inhibitors. The study analyzed 16 hydroxybenzoic acids using calorimetry and docking simulation as AChE inhibitors. All tested compounds were shown to inhibit the hydrolysis of ACh. The best properties ...[more]