In Silico Screening and Testing of FDA-Approved Small Molecules to Block SARS-CoV-2 Entry to the Host Cell by Inhibiting Spike Protein Cleavage.
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ABSTRACT:
SUBMITTER: Ozdemir ES
PROVIDER: S-EPMC9231362 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
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In Silico Screening and Testing of FDA-Approved Small Molecules to Block SARS-CoV-2 Entry to the Host Cell by Inhibiting Spike Protein Cleavage.
Ozdemir E Sila ES Le Hillary H HH Yildirim Adem A Ranganathan Srivathsan V SV
Viruses 20220524 6
The COVID-19 pandemic began in 2019, but it is still active. The development of an effective vaccine reduced the number of deaths; however, a treatment is still needed. Here, we aimed to inhibit viral entry to the host cell by inhibiting spike (S) protein cleavage by several proteases. We developed a computational pipeline to repurpose FDA-approved drugs to inhibit protease activity and thus prevent S protein cleavage. We tested some of our drug candidates and demonstrated a decrease in protease ...[more]
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