Dataset Information

Sex differences in neurobehavioral consequences of methamphetamine exposure in adult mice.

ABSTRACT:

Rationale

Recreational and medical use of stimulants is increasing, and their use may increase susceptibility to aging and promote neurobehavioral impairments. The long-term consequences of these psychostimulants and how they interact with age have not been fully studied.

Objectives

Our study investigated whether chronic exposure to the prototypical psychostimulant, methamphetamine (METH), at doses designed to emulate human therapeutic dosing, would confer a pro-oxidizing redox shift promoting long-lasting neurobehavioral impairments.

Methods

Groups of 4-month-old male and female C57BL/6 J mice were administered non-contingent intraperitoneal injections of either saline or METH (1.4 mg/kg) twice a day for 4 weeks. Mice were randomly assigned to one experimental group: (i) short-term cognitive assessments (at 5 months), (ii) long-term cognitive assessments (at 9.5 months), and (ii) longitudinal motor assessments (at 5, 7, and 9 months). Brain regions were assessed for oxidative stress and markers of neurotoxicity after behavior testing.

Results

Chronic METH exposure induced short-term effects on associative memory, gait speed, dopamine (DA) signaling, astrogliosis in females, and spatial learning and memory, balance, DA signaling, and excitotoxicity in males. There were no long-term effects of chronic METH on cognition; however, it decreased markers of excitotoxicity in the striatum and exacerbated age-associated motor impairments in males.

Conclusion

In conclusion, cognitive and motor functions were differentially and sex-dependently affected by METH exposure, and oxidative stress did not seem to play a role in the observed behavioral outcomes. Future studies are necessary to continue exploring the long-term neurobehavioral consequences of drug use in both sexes and the relationship between aging and drugs.

SUBMITTER: Davis DL

PROVIDER: S-EPMC9232998 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature

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Publications

Sex differences in neurobehavioral consequences of methamphetamine exposure in adult mice.

Davis Delaney L DL Metzger Daniel B DB Vann Philip H PH Wong Jessica M JM Subasinghe Kumudu H KH Garlotte Isabelle K IK Phillips Nicole R NR Shetty Ritu A RA Forster Michael J MJ Sumien Nathalie N

Psychopharmacology 20220326 7

<h4>Rationale</h4>Recreational and medical use of stimulants is increasing, and their use may increase susceptibility to aging and promote neurobehavioral impairments. The long-term consequences of these psychostimulants and how they interact with age have not been fully studied.<h4>Objectives</h4>Our study investigated whether chronic exposure to the prototypical psychostimulant, methamphetamine (METH), at doses designed to emulate human therapeutic dosing, would confer a pro-oxidizing redox sh ...[more]

PMID: 35347365

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Dataset Information

Sex differences in neurobehavioral consequences of methamphetamine exposure in adult mice.

Rationale

Objectives

Methods

Results

Conclusion

Publications

Sex differences in neurobehavioral consequences of methamphetamine exposure in adult mice.

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