Targeting fungal membrane homeostasis with imidazopyrazoindoles impairs azole resistance and biofilm formation.
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ABSTRACT:
SUBMITTER: Revie NM
PROVIDER: S-EPMC9233667 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
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Targeting fungal membrane homeostasis with imidazopyrazoindoles impairs azole resistance and biofilm formation.
Revie Nicole M NM Iyer Kali R KR Maxson Michelle E ME Zhang Jiabao J Yan Su S Fernandes Caroline M CM Meyer Kirsten J KJ Chen Xuefei X Skulska Iwona I Fogal Meea M Sanchez Hiram H Hossain Saif S Li Sheena S Yashiroda Yoko Y Hirano Hiroyuki H Yoshida Minoru M Osada Hiroyuki H Boone Charles C Shapiro Rebecca S RS Andes David R DR Wright Gerard D GD Nodwell Justin R JR Del Poeta Maurizio M Burke Martin D MD Whitesell Luke L Robbins Nicole N Cowen Leah E LE
Nature communications 20220625 1
Fungal infections cause more than 1.5 million deaths annually. With an increase in immune-deficient susceptible populations and the emergence of antifungal drug resistance, there is an urgent need for novel strategies to combat these life-threatening infections. Here, we use a combinatorial screening approach to identify an imidazopyrazoindole, NPD827, that synergizes with fluconazole against azole-sensitive and -resistant isolates of Candida albicans. NPD827 interacts with sterols, resulting in ...[more]
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