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Sulfur regulation of the sulfate transporter genes sutA and sutB in Penicillium chrysogenum.

ABSTRACT: Penicillium chrysogenum uses sulfate as a source of sulfur for the biosynthesis of penicillin. Sulfate uptake and the mRNA levels of the sulfate transporter-encoding sutB and sutA genes are all reduced by high sulfate concentrations and are elevated by sulfate starvation. In a high-penicillin-yielding strain, sutB is effectively transcribed even in the presence of excess sulfate. This deregulation may facilitate the efficient incorporation of sulfur into cysteine and penicillin.

SUBMITTER: van de Kamp M

PROVIDER: S-EPMC92338 | biostudies-literature | 2000 Oct

REPOSITORIES: biostudies-literature

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Sulfur regulation of the sulfate transporter genes sutA and sutB in Penicillium chrysogenum.

van de Kamp M M Schuurs T A TA Vos A A van der Lende T R TR Konings W N WN Driessen A J AJ

Applied and environmental microbiology 20001001 10

Penicillium chrysogenum uses sulfate as a source of sulfur for the biosynthesis of penicillin. Sulfate uptake and the mRNA levels of the sulfate transporter-encoding sutB and sutA genes are all reduced by high sulfate concentrations and are elevated by sulfate starvation. In a high-penicillin-yielding strain, sutB is effectively transcribed even in the presence of excess sulfate. This deregulation may facilitate the efficient incorporation of sulfur into cysteine and penicillin. ...[more]

PMID: 11010912

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