Ontology highlight
ABSTRACT:
SUBMITTER: Dibus N
PROVIDER: S-EPMC9234700 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Dibus Nikol N Zobalova Eliska E Monleon Mario A M MAM Korinek Vladimir V Filipp Dominik D Petrusova Jana J Sedlacek Radislav R Kasparek Petr P Cermak Lukas L
Frontiers in cell and developmental biology 20220613
The ubiquitin ligase SCF<sup>FBXO38</sup> controls centromeric chromatin by promoting the degradation of the ZXDB protein. To determine the importance of this pathway during development, <i>Fbxo38</i>-deficient mice were generated. The loss of FBXO38 resulted in growth retardation affecting several organs, including the male reproductive system. A detailed analysis of the mutant testes revealed pathological changes in the seminiferous tubules, accompanied by a significant decrease in sperm produ ...[more]