Ontology highlight
ABSTRACT:
SUBMITTER: Gibellini L
PROVIDER: S-EPMC9237102 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
Gibellini Lara L Borella Rebecca R De Gaetano Anna A Zanini Giada G Tartaro Domenico Lo DL Carnevale Gianluca G Beretti Francesca F Losi Lorena L De Biasi Sara S Nasi Milena M Forcato Mattia M Cossarizza Andrea A Pinti Marcello M
Scientific reports 20220627 1
The coordinated communication between the mitochondria and nucleus is essential for cellular activities. Nonetheless, the pathways involved in this crosstalk are scarcely understood. The protease Lonp1 was previously believed to be exclusively located in the mitochondria, with an important role in mitochondrial morphology, mtDNA maintenance, and cellular metabolism, in both normal and neoplastic cells. However, we recently detected Lonp1 in the nuclear, where as much as 22% of all cellular Lonp1 ...[more]