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Experimental verification of generalized eigenstate thermalization hypothesis in an integrable system.

ABSTRACT: Identifying the general mechanics behind the equilibration of a complex isolated quantum system towards a state described by only a few parameters has been the focus of attention in non-equilibrium thermodynamics. And several experimentally unproven conjectures are proposed for the statistical description of quantum (non-)integrable models. The plausible eigenstate thermalization hypothesis (ETH), which suggests that each energy eigenstate itself is thermal, plays a crucial role in understanding the quantum thermalization in non-integrable systems; it is commonly believed that it does not exist in integrable systems. Nevertheless, integrable systems can still relax to the generalized Gibbs ensemble. From a microscopic perspective, understanding the origin of this generalized thermalization that occurs in an isolated integrable system is a fundamental open question lacking experimental investigations. Herein, we experimentally investigated the spin subsystem relaxation in an isolated spin-orbit coupling quantum system. By applying the quantum state engineering technique, we initialized the system with various distribution widths in the mutual eigenbasis of the conserved quantities. Then, we compared the steady state of the spin subsystem reached in a long-time coherent dynamics to the prediction of a generalized version of ETH and the underlying mechanism of the generalized thermalization is experimentally verified for the first time. Our results facilitate understanding the origin of quantum statistical mechanics.

SUBMITTER: Wang QQ

PROVIDER: S-EPMC9239999 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Project description:BACKGROUND: The development of new anticoagulants is an important goal for the improvement of thromboses treatments. OBJECTIVES: The design, synthesis and experimental testing of new safe and effective small molecule direct thrombin inhibitors for intravenous administration. METHODS: Computer-aided molecular design of new thrombin inhibitors was performed using our original docking program SOL, which is based on the genetic algorithm of global energy minimization in the framework of a Merck Molecular Force Field. This program takes into account the effects of solvent. The designed molecules with the best scoring functions (calculated binding energies) were synthesized and their thrombin inhibitory activity evaluated experimentally in vitro using a chromogenic substrate in a buffer system and using a thrombin generation test in isolated plasma and in vivo using the newly developed model of hemodilution-induced hypercoagulation in rats. The acute toxicities of the most promising new thrombin inhibitors were evaluated in mice, and their stabilities in aqueous solutions were measured. RESULTS: New compounds that are both effective direct thrombin inhibitors (the best K(I) was <1 nM) and strong anticoagulants in plasma (an IC(50) in the thrombin generation assay of approximately 100 nM) were discovered. These compounds contain one of the following new residues as the basic fragment: isothiuronium, 4-aminopyridinium, or 2-aminothiazolinium. LD(50) values for the best new inhibitors ranged from 166.7 to >1111.1 mg/kg. A plasma-substituting solution supplemented with one of the new inhibitors prevented hypercoagulation in the rat model of hemodilution-induced hypercoagulation. Activities of the best new inhibitors in physiological saline (1 µM solutions) were stable after sterilization by autoclaving, and the inhibitors remained stable at long-term storage over more than 1.5 years at room temperature and at 4°C. CONCLUSIONS: The high efficacy, stability and low acute toxicity reveal that the inhibitors that were developed may be promising for potential medical applications.

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Experimental verification of generalized eigenstate thermalization hypothesis in an integrable system.

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