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Cu-catalyzed carboboration of acetylene with Michael acceptors.

ABSTRACT: A copper-catalyzed three-component carboboration of acetylene with B₂Pin₂ and Michael acceptors is reported. In this reaction, a cheap and abundant C2 chemical feedstock, acetylene, was used as a starting material to afford cis-alkenyl boronates bearing a homoallylic carbonyl group. The reaction was robust and could be reliably performed on the molar scale. Furthermore, the resulting cis-alkenyl boronates could be converted to diverse functionalized molecules with ease.

SUBMITTER: Cheng T

PROVIDER: S-EPMC9241969 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature

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Cu-catalyzed carboboration of acetylene with Michael acceptors.

Cheng Tairan T Liu Boxiang B Wu Rui R Zhu Shifa S

Chemical science 20220608 25

A copper-catalyzed three-component carboboration of acetylene with B2Pin2 and Michael acceptors is reported. In this reaction, a cheap and abundant C2 chemical feedstock, acetylene, was used as a starting material to afford cis-alkenyl boronates bearing a homoallylic carbonyl group. The reaction was robust and could be reliably performed on the molar scale. Furthermore, the resulting cis-alkenyl boronates could be converted to diverse functionalized molecules ...[more]

PMID: 35872813

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