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The central clock suffices to drive the majority of circulatory metabolic rhythms.

ABSTRACT: Life on Earth anticipates recurring 24-hour environmental cycles via genetically encoded molecular clocks active in all mammalian organs. Communication between these clocks controls circadian homeostasis. Intertissue communication is mediated, in part, by temporal coordination of metabolism. Here, we characterize the extent to which clocks in different organs control systemic metabolic rhythms, an area that remains largely unexplored. We analyzed the metabolome of serum from mice with tissue-specific expression of the clock gene Bmal1. Having functional hepatic and muscle clocks can only drive a minority (13%) of systemic metabolic rhythms. Conversely, limiting Bmal1 expression to the central pacemaker in the brain restores rhythms to 57% of circulatory metabolites. Rhythmic feeding imposed on clockless mice resulted in a similar rescue, indicating that the central clock mainly regulates metabolic rhythms via behavior. These findings explicate the circadian communication between tissues and highlight the importance of the central clock in governing those signals.

SUBMITTER: Petrus P

PROVIDER: S-EPMC9242453 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Project description:The intricately fluctuating onset of respiratory and circulatory diseases displays rhythms of multi-scaled meteorological conditions due to their sensitivity to weather changes. The intrinsic meteorological rhythms of these diseases are revealed in this bio-meteorological study via Fourier decomposition and harmonic analysis. Daily emergency room (ER) visit data for respiratory and circulatory diseases from three comprehensive hospitals in Haidian district of Beijing, China were used in the analysis. Meteorological data included three temperature metrics, relative humidity, sunshine duration, daily mean air pressure, and wind speed. The Fourier decomposition and harmonic analysis on ER visits and meteorological variables involve frequency, period, and power of all harmonics. The results indicated that: i) for respiratory morbidity, a strong climatic annual rhythm responding to annual temperature change was firstly revealed; its ratio of spectral density was 16-33%. Moreover, significant correlations existed between the high-frequency fluctuations (<30 d) of morbidity and short-term harmonics of humidity and solar duration. High-frequency harmonics of temperature and pressure showed no statistically significant effect. ii) With regard to all types of circulatory morbidity, their annual periodicity was weaker than that of respiratory diseases, whose harmonic energy took a ratio less than 8%. Besides, the power of all high-frequency harmonics of circulatory morbidity accounted for up to 70-90% in the original sequences, and their relationship to many short-term meteorological factors were significant, including the mean and maximum temperatures, wind speed, and solar duration. iii) The weekly rhythm appeared in respiratory ER visits with 15% of harmonic variance but not prominent in circulatory morbidity. In summary, by decomposing the sequence of respiratory and circulatory diseases as well as recognizing their meteorological rhythms, different responses to meteorological conditions on various time scales were identified.

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The central clock suffices to drive the majority of circulatory metabolic rhythms.

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