Mathematical modelling of cross-linked polyacrylic-based hydrogels: physical properties and drug delivery.

ABSTRACT: Recently, hydrogels have gained significant importance in different applications, such as tissue engineering and drug delivery. They are 3D structures of hydrophilic polymers held together through physical or chemical crosslinking. Important is their ability to swell in presence of solvents, forming elastic gels able to maintain their original shape. Furthermore, these scaffolds slowly degrade in the physiological environment, leading the growing tissue to replace the former filled site. In this work, hydrogels have been synthetized using branched polyacrylic acid (carbomer) cross-linked with an aliphatic polyetherdiamine (elastamine). In particular, we focused on the description of their equilibrium conditions in swollen state and the dynamic simulation of the swelling process. These hydr

SUBMITTER: Bisotti F 

PROVIDER: S-EPMC9242946 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature