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Effects of context and discrepancy when reading multiple documents.

ABSTRACT: On a daily basis, most people read about issues of interest from a diversity of sources. Moreover, the information they encounter frequently encompass discrepancies, ranging from minor inconsistencies to straight contradictions. Readers may construct coherent representations from discrepant contents by linking contents to their respective sources and connecting the sources with agree-disagree or other types of connectives. Across research studies, however, college-level readers' attention to sources has been found to vary according to individual, text and task dimensions. The present study tested the assumption that readers' strategies depend both on the discrepancy of the information and on the context in which the task is framed. Moreover, beliefs about science were included as potential moderator of context effects. One hundred and sixty university students were tasked to read about a series of social-scientific issues. The task was framed in either a university context or a personal context scenario. For each topic, the participants read two short texts which provided either consistent or discrepant information, and then they wrote a short overview essay. The university context had a significant impact on indicators related to a documents model representation (e.g., text switches, number of adversative connectors in the essay) and standards for presentation (e.g., time on the essay/task page, formal features of the essay). The data support a context-dependent view of reading comprehension, whereby both reading behavior and outcomes are primarily a function of the standards and goals set by the reader.

Supplementary information

The online version contains supplementary material available at 10.1007/s11145-022-10321-2.

SUBMITTER: Schoor C

PROVIDER: S-EPMC9244203 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Project description:BACKGROUND: Previous studies have documented strategies to promote off-label use of drugs using journal publications and other means. Few studies have presented internal company communications that discussed financial reasons for manipulating the scholarly record related to off-label indications. The objective of this study was to build on previous studies to illustrate implementation of a publication strategy by the drug manufacturer for four off-label uses of gabapentin (Neurontin, Pfizer, Inc.): migraine prophylaxis, treatment of bipolar disorders, neuropathic pain, and nociceptive pain. METHODS: We included in this study internal company documents, email correspondence, memoranda, study protocols and reports that were made publicly available in 2008 as part of litigation brought by consumers and health insurers against Pfizer for fraudulent sales practices in its marketing of gabapentin (see http://pacer.mad.uscourts.gov/dc/cgi-bin/recentops.pl?filename=saris/pdf/ucl%20opinion.pdf for the Court's findings).We reviewed documents pertaining to 20 clinical trials, 12 of which were published. We categorized our observations related to reporting biases and linked them with topics covered in internal documents, that is, deciding what should and should not be published and how to spin the study findings (re-framing study results to explain away unfavorable findings or to emphasize favorable findings); and where and when findings should be published and by whom. RESULTS: We present extracts from internal company marketing assessments recommending that Pfizer and Parke-Davis (Pfizer acquired Parke-Davis in 2000) adopt a publication strategy to conduct trials and disseminate trial findings for unapproved uses rather than an indication strategy to obtain regulatory approval. We show internal company email correspondence and documents revealing how publication content was influenced and spin was applied; how the company selected where trial findings would be presented or published; how publication of study results was delayed; and the role of ghost authorship. CONCLUSIONS: Taken together, the extracts we present from internal company documents illustrate implementation of a strategy at odds with unbiased study conduct and dissemination. Our findings suggest that Pfizer and Parke-Davis's publication strategy had the potential to distort the scientific literature, and thus misinform healthcare decision-makers.

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Effects of context and discrepancy when reading multiple documents.

Supplementary information

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