Transformation of Amphiphilic Antiviral Drugs into New Dimensional Nanovesicles Structures.

ABSTRACT: Improved techniques were applied to formulate drugs into dimensional nanostructures, doped "nanovesicles". These nanovesicles are solely composed of self-assembled amphiphilic antiviral agents used for the treatment of viral infections caused by flaviviruses, such as Zika virus. Studies were done to evaluate the effectiveness of the syntheses, formation, and performance under different experimental conditions, and behavior of the drug nanovesicles in vitro and in vivo. These studies demonstrated that assembling the hydrophobic antiviral drug molecules into nanodrugs is a successful technique for the delivery of the therapeutic agents, otherwise difficult to be supplied. Our studies confirmed that this nanodrug preserved and, in many cases, enhanced the embedded cellular activ

SUBMITTER: Hamdan S 

PROVIDER: S-EPMC9244911 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature