Browse
Submit Data
Databases
API
Help

Dataset Information

26 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Geometrically Induced Selectivity and Unidirectional Electroosmosis in Uncharged Nanopores.

ABSTRACT: Selectivity toward positive and negative ions in nanopores is often associated with electroosmotic flow, the control of which is pivotal in several micro-nanofluidic technologies. Selectivity is traditionally understood to be a consequence of surface charges that alter the ion distribution in the pore lumen. Here we present a purely geometrical mechanism to induce ionic selectivity and electroosmotic flow in uncharged nanopores, and we tested it via molecular dynamics simulations. Our approach exploits the accumulation of charges, driven by an external electric field, in a coaxial cavity that decorates the membrane close to the pore entrance. The selectivity was shown to depend on the applied voltage and becomes completely inverted when reversing the voltage. The simultaneous inversion of ionic selectivity and electric field direction causes a unidirectional electroosmotic flow. We developed a quantitatively accurate theoretical model for designing pore geometry to achieve the desired electroosmotic velocity. Finally, we show that unidirectional electroosmosis also occurs in much more complex scenarios, such as a biological pore whose structure presents a coaxial cavity surrounding the pore constriction as well as a complex surface charge pattern. The capability to induce ion selectivity without altering the pore lumen shape or the surface charge may be useful for a more flexible design of selective membranes.

SUBMITTER: Di Muccio G

PROVIDER: S-EPMC9245180 | biostudies-literature |

REPOSITORIES: biostudies-literature

ACCESS DATA

Json Xml

Similar Datasets

Multifrequency Induced-Charge Electroosmosis.

Project description:We present herein a unique concept of multifrequency induced-charge electroosmosis (MICEO) actuated directly on driving electrode arrays, for highly-efficient simultaneous transport and convective mixing of fluidic samples in microscale ducts. MICEO delicately combines transversal AC electroosmotic vortex flow, and axial traveling-wave electroosmotic pump motion under external dual-Fourier-mode AC electric fields. The synthetic flow field associated with MICEO is mathematically analyzed under thin layer limit, and the particle tracing experiment with a special powering technique validates the effectiveness of this physical phenomenon. Meanwhile, the simulation results with a full-scale 3D computation model demonstrate its robust dual-functionality in inducing fully-automated analyte transport and chaotic stirring in a straight fluidic channel embedding double-sided quarter-phase discrete electrode arrays. Our physical demonstration with multifrequency signal control on nonlinear electroosmosis provides invaluable references for innovative designs of multifunctional on-chip analytical platforms in modern microfluidic systems.

| S-EPMC6680487 | biostudies-literature

Ion selectivity of graphene nanopores.

Project description:As population growth continues to outpace development of water infrastructure in many countries, desalination (the removal of salts from seawater) at high energy efficiency will likely become a vital source of fresh water. Due to its atomic thinness combined with its mechanical strength, porous graphene may be particularly well-suited for electrodialysis desalination, in which ions are removed under an electric field via ion-selective pores. Here, we show that single graphene nanopores preferentially permit the passage of K(+) cations over Cl(-) anions with selectivity ratios of over 100 and conduct monovalent cations up to 5 times more rapidly than divalent cations. Surprisingly, the observed K(+)/Cl(-) selectivity persists in pores even as large as about 20 nm in diameter, suggesting that high throughput, highly selective graphene electrodialysis membranes can be fabricated without the need for subnanometer control over pore size.

| S-EPMC4844701 | biostudies-literature

Analytical Model for Particle Capture in Nanopores Elucidates Competition among Electrophoresis, Electroosmosis, and Dielectrophoresis.

Project description:The interaction between nanoparticles dispersed in a fluid and nanopores is governed by the interplay of hydrodynamical, electrical, and chemical effects. We developed a theory for particle capture in nanopores and derived analytical expressions for the capture rate under the concurrent action of electrical forces, fluid advection, and Brownian motion. Our approach naturally splits the average capture time in two terms, an approaching time due to the migration of particles from the bulk to the pore mouth and an entrance time associated with a free-energy barrier at the pore entrance. Within this theoretical framework, we described the standard experimental condition where a particle concentration is driven into the pore by an applied voltage, with specific focus on different capture mechanisms: under pure electrophoretic force, in the presence of a competition between electrophoresis and electroosmosis, and finally under dielectrophoretic reorientation of dipolar particles. Our theory predicts that dielectrophoresis is able to induce capture for both positive and negative voltages. We performed a dedicated experiment involving a biological nanopore (α-hemolysin) and a rigid dipolar dumbbell (realized with a β-hairpin peptide) that confirms the theoretically proposed capture mechanism.

| S-EPMC8016366 | biostudies-literature

Ionic selectivity and filtration from fragmented dehydration in multilayer graphene nanopores.

Project description:Selective ion transport is a hallmark of biological ion channel behavior but is a major challenge to engineer into artificial membranes. Here, we demonstrate, with all-atom molecular dynamics simulations, that bare graphene nanopores yield measurable ion selectivity that varies over one to two orders of magnitude simply by changing the pore radius and number of graphene layers. Monolayer graphene does not display dehydration-induced selectivity until the pore radius is small enough to exclude the first hydration layer from inside the pore. Bi- and tri-layer graphene, though, display such selectivity already for a pore size that barely encroaches on the first hydration layer, which is due to the more significant water loss from the second hydration layer. Measurement of selectivity and activation barriers from both first and second hydration layer barriers will help elucidate the behavior of biological ion channels. Moreover, the energy barriers responsible for selectivity - while small on the scale of hydration energies - are already relatively large, i.e., many kBT. For separation of ions from water, therefore, one can exchange longer, larger radius pores for shorter, smaller radius pores, giving a practical method for maintaining exclusion efficiency while enhancing other properties (e.g., water throughput).

| S-EPMC5604754 | biostudies-literature

Artificial nanopores that mimic the transport selectivity of the nuclear pore complex.

Project description:Nuclear pore complexes (NPCs) act as effective and robust gateways between the nucleus and the cytoplasm, selecting for the passage of particular macromolecules across the nuclear envelope. NPCs comprise an elaborate scaffold that defines a approximately 30 nm diameter passageway connecting the nucleus and the cytoplasm. This scaffold anchors proteins termed 'phenylalanine-glycine' (FG)-nucleoporins, the natively disordered domains of which line the passageway and extend into its lumen. Passive diffusion through this lined passageway is hindered in a size-dependent manner. However, transport factors and their cargo-bound complexes overcome this restriction by transient binding to the FG-nucleoporins. To test whether a simple passageway and a lining of transport-factor-binding FG-nucleoporins are sufficient for selective transport, we designed a functionalized membrane that incorporates just these two elements. Here we demonstrate that this membrane functions as a nanoselective filter, efficiently passing transport factors and transport-factor-cargo complexes that specifically bind FG-nucleoporins, while significantly inhibiting the passage of proteins that do not. This inhibition is greatly enhanced when transport factor is present. Determinants of selectivity include the passageway diameter, the length of the nanopore region coated with FG-nucleoporins, the binding strength to FG-nucleoporins, and the antagonistic effect of transport factors on the passage of proteins that do not specifically bind FG-nucleoporins. We show that this artificial system faithfully reproduces key features of trafficking through the NPC, including transport-factor-mediated cargo import.

| S-EPMC2764719 | biostudies-literature

Self-Induced Convection at Microelectrodes via Electroosmosis and Its Influence on Impact Electrochemistry.

Project description:Faradaic reactions at low supporting electrolyte concentrations induce convection via electroosmotic flows. Here we combine finite-element simulations and electrochemical measurements on microparticles at ultramicroelectrodes to explore this effect. We show that convection becomes the dominant form of mass transport for experiments at low salt concentrations, violating the common assumption that convection can be neglected.

| S-EPMC7582615 | biostudies-literature

Unidirectional invisibility induced by parity-time symmetric circuit.

Project description:Parity-time (PT) symmetric structures present the unidirectional invisibility at the spontaneous PT-symmetry breaking point. In this paper, we propose a PT-symmetric circuit consisting of a resistor and a microwave tunnel diode (TD) which represent the attenuation and amplification, respectively. Based on the scattering matrix method, the circuit can exhibit an ideal unidirectional performance at the spontaneous PT-symmetry breaking point by tuning the transmission lines between the lumped elements. Additionally, the resistance of the reactance component can alter the bandwidth of the unidirectional invisibility flexibly. Furthermore, the electromagnetic simulation for the proposed circuit validates the unidirectional invisibility and the synchronization with the input energy well. Our work not only provides an unidirectional invisible circuit based on PT-symmetry, but also proposes a potential solution for the extremely selective filter or cloaking applications.

| S-EPMC5241775 | biostudies-literature

Chirality-Induced Giant Unidirectional Magnetoresistance in Twisted Bilayer Graphene.

Project description:Twisted bilayer graphene (TBG) exhibits fascinating correlation-driven phenomena like the superconductivity and Mott insulating state, with flat bands and a chiral lattice structure. We find by quantum-transport calculations that the chirality leads to a giant unidirectional magnetoresistance (UMR) in TBG, where the unidirectionality refers to the resistance change under the reversal of the direction of current or magnetic field. We point out that flat bands significantly enhance this effect. The UMR increases quickly upon reducing the twist angle, and reaches about 20% for an angle of 1.5° in a 10 T in-plane magnetic field. We propose the band structure topology (asymmetry), which leads to a direction-sensitive mean free path, as a useful way to anticipate the UMR effect. The UMR provides a probe for chirality and band flatness in the twisted bilayers.

| S-EPMC7938422 | biostudies-literature

Sequence selectivity of macrolide-induced translational regulation

Project description:We sequenced a total of 12 cDNA libararies derived from fragmented total mRNA and ribosome protected mRNAs from azithromycin-treated and -untreated S. aureus samples. The data represented 2 independent biological replicates. Examination of the impact of azithromycin on global translatome, mRNA abundance and the ribosome density along the transcripts.

2014-11-03 | E-GEOD-57175 | biostudies-arrayexpress

Self-assembly of two robust 3D supramolecular organic frameworks from a geometrically non-planar molecule for high gas selectivity performance.

Project description:The synthesis of highly porous frameworks has received continuous research interest, but achieving the ability to target stable and selective materials remains challenging. Herein, by utilizing a 'direction-oriented' strategy and modulating reaction conditions, two novel 3D porous supramolecular organic framework (SOF) materials (JLU-SOF2 and JLU-SOF3, as isomers) are assembled from a non-planar building block (TMBTI = 2,4,6-trimethyl benzene-1,3,5-triyl-isophthalic acid) and they display permanent porosity, high thermal stability, and good recyclability. It is worth mentioning that the CO2 uptake values of JLU-SOF2 and JLU-SOF3 rank among the highest values for SOF-based materials under ambient conditions. Furthermore, these two materials exhibit preferential adsorption of CO2 over N2 and CH4, and can effectively separate the mixtures of light hydrocarbons. These studies indicate the possible application of JLU-SOF2 and JLU-SOF3 in trapping greenhouse gases and upgrading natural gas. In addition, this synthetic strategy introduces an effective method for developing remarkable 3D SOFs among other framework materials.

| S-EPMC6615216 | biostudies-literature

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data