Dynamic Reconfiguration of Subcompartment Architectures in Artificial Cells.

ABSTRACT: Artificial cells are minimal structures constructed from biomolecular building blocks designed to mimic cellular processes, behaviors, and architectures. One near-ubiquitous feature of cellular life is the spatial organization of internal content. We know from biology that organization of content (including in membrane-bound organelles) is linked to cellular functions and that this feature is dynamic: the presence, location, and degree of compartmentalization changes over time. Vesicle-based artificial cells, however, are not currently able to mimic this fundamental cellular property. Here, we describe an artificial cell design strategy that addresses this technological bottleneck. We create a series of artificial cell architectures which possess multicompartment assemblies localized eithe

SUBMITTER: Zubaite G 

PROVIDER: S-EPMC9245354 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature