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Magnitude of mitral valve closure plays a pivotal role in enhancing the forward blood flow during cardiac massage in dogs with ventricular fibrillation.

ABSTRACT: Motion of mitral valve during cardiac massage was examined using beagle dogs with ventricular fibrillation (n=4). Active compression-decompression cardiac massage (ACD-CM) exhibited greater peak aortic pressure than standard cardiac massage (S-CM), reverse of which was true for peak pulmonary capillary wedge pressure in each animal. Accordingly, peak aortic pressure was greater than peak pulmonary capillary wedge pressure with ACD-CM, whereas its reverse was true with S-CM. Transesophageal echocardiography revealed that mitral valve was incompletely closed with S-CM with showing regurgitation. The valve was more effectively closed during ACD-CM. These results indicate that effective closure of mitral valve during cardiac massage may increase forward blood flow, supporting "cardiac pump theory" rather than "thoracic pump theory" as a principle in dogs.

SUBMITTER: Goto A

PROVIDER: S-EPMC9246689 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Genomic expression patterns of mitral valve tissues from dogs with degenerative mitral valve disease

Project description:Evaluation of global expression patterns provides a molecular portrait of mitral valve disease, yields insight into the pathophysiologic aspects of DMVD, and identifies intriguing genes and pathways for further study. (Am J Vet Res 2006;67:1307–1318) Keywords: control vs diseased 4 controls( beagle crosses) and 4 affected (1 Daschund, 1 Lhasa apso, 2 miniature poodles)

2008-05-15 | E-GEOD-11460 | biostudies-arrayexpress

Genomic expression patterns of mitral valve tissues from dogs with degenerative mitral valve disease

2008-05-15 | GSE11460 | GEO

Retrograde transcatheter closure of anterior mitral valve leaflet perforation.

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| S-EPMC6716313 | biostudies-literature

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| S-EPMC3760036 | biostudies-literature

Pathogenesis of mitral valve disease in mucopolysaccharidosis VII dogs.

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| S-EPMC3800211 | biostudies-literature

Plasmatic Dimethylarginines in Dogs With Myxomatous Mitral Valve Disease.

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Prognostic value of forward flow indices in primary mitral regurgitation due to mitral valve prolapse.

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| S-EPMC9995829 | biostudies-literature

Echocardiographic indices and severity of mitral regurgitation in dogs with preclinical degenerative mitral valve disease.

Project description:BackgroundDescribing severity of mitral regurgitation (MR) in dogs with degenerative mitral valve disease (DMVD) is challenging.Hypothesis/objectivesMitral regurgitant fraction (RF), effective regurgitant orifice area (EROA), and the ratio of mitral regurgitant to aortic flow (QMR :QAo ) can be calculated from routine echocardiographic measurements and provide additional information regarding MR severity.AnimalsFifty-seven dogs with preclinical DMVD including 36 without and 21 with cardiomegaly.MethodsProspective observational study. The expected relationships among RF, EROA, and QMR :QAo and 1-dimensional measurements including left atrium to aortic root diameter ratio (LA:Ao) and normalized left ventricular internal dimension at end-diastole (LVIDdN) were mathematically derived and calculated using echocardiographic data from the study population. Nonlinear goodness of fit was determined by calculation of the root mean standard error. The correlations between 1-dimensional and multidimensional indices were analyzed using receiver operating characteristic curves.ResultsThe relationships among RF, EROA, QMR :QAo , and both LA:Ao and LVIDdN were curvilinear, and the multidimensional indices differentiated MR of variable severity. By contrast, 1-dimensional measurements were insensitive to MR severity until RF equaled or exceeded 50%. Regurgitant fraction ≥50%, EROA to body surface area ≥0.347 and QMR :QAo ≥0.79 were strongly associated with LA:Ao ≥1.6 and LVIDdN ≥1.7.Conclusions and clinical importanceRegurgitant fraction, EROA, and QMR :QAo quantify MR severity in dogs with preclinical DMVD in a manner that 1-dimensional measurements do not.

| S-EPMC6430891 | biostudies-literature

Mitral valve interstitial Tissue: Myxomatous P2 prolapse of the mitral valve vs. Control

Project description:Aim: Test the hypothesis that 5HT receptors (5HTRs) signaling contributes to MVP pathophysiology. Methods and results: MV RNA was used for microarray analysis of MVP patients versus control, highlighting genes that indicate the involvement of 5HTR pathways and extracellular matrix remodeling in MVP. These canine MVP leaflets (N=5/group) showed 5HTR2B upregulation. Conclusion: In humans, MVP is associated with an upregulation in 5HTR2B expression and increased 5HT receptor signaling in the leaflets. 5HTR signaling is involved not only in previously reported 5HTrelated valvulopathies, but it is also involved in the pathological remodeling of MVP.

2018-01-29 | GSE109744 | GEO

Clinical severity score system in dogs with degenerative mitral valve disease.

Project description:BackgroundSeveral risk factors already have been determined for dogs with degenerative mitral valve disease (DMVD). Risk factors often have been considered in isolation and have not always taken into account additional information provided by the history and physical examination (PE).Hypothesis/objectivesData obtained from history and PE of dogs with DMVD provide prognostic information and can be used for risk stratification.AnimalsClient-owned dogs (n = 244) with DMVD recruited from first opinion practice.MethodsProspective longitudinal follow-up of dogs with DMVD. History and PE data were obtained at 6-month intervals and analyzed with time-dependent Cox models to derive relative risk of cardiac death. Independent hazard ratios were used to derive a clinical severity score (CSS), the prognostic value of which was evaluated by analyzing the median survival times for different risk groups and ROC analysis. Analysis of the progression of CSS over time also was undertaken.ResultsHistory of cough, exercise intolerance, decreased appetite, breathlessness (difficulty breathing) and syncope with PE findings of heart murmur intensity louder than III/VI and absence of respiratory sinus arrhythmia were independently associated with outcome and allowed development of the CSS. Clinical severity score distinguished groups of dogs with significantly different outcomes.Conclusions and clinical importanceRoutinely obtained clinical findings allow risk stratification of dogs with DMVD. Results of ancillary diagnostic tests may be complementary to history and PE findings and always should be interpreted in conjunction with these findings.

| S-EPMC4895509 | biostudies-literature

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