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The effect of mesenchymal stem cells improves the healing of burn wounds: a phase 1 dose-escalation clinical trial.
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ABSTRACT:
SUBMITTER: Schulman CI
PROVIDER: S-EPMC9247372 | biostudies-literature | 2022 Jan-Dec
REPOSITORIES: biostudies-literature
Publications
The effect of mesenchymal stem cells improves the healing of burn wounds: a phase 1 dose-escalation clinical trial.
Scars, burns & healing 20220101
<h4>Background</h4>Stem cell therapy holds promise to improve healing and stimulate tissue regeneration after burn injury. Preclinical evidence has supported this; however, clinical studies are lacking. We examined the application of bone marrow-derived mesenchymal stem cells (BM-MSC) to deep second-degree burn injuries using a two-dose escalation protocol.<h4>Methods</h4>Ten individuals aged 18 years or older with deep second-degree burn wounds were enrolled. The first five patients were admini ...[more]