Post-Ganglionic Sympathetic Neurons can Directly Sense Raised Extracellular Na⁺ via SCN7a/Na_x.

ABSTRACT: The relationship between dietary NaCl intake and high blood pressure is well-established, and occurs primarily through activation of the sympathetic nervous system. Na_x, a Na⁺-sensitive Na⁺ channel, plays a pivotal role in driving sympathetic excitability, which is thought to originate from central regions controlling neural outflow. We investigated whether post-ganglionic sympathetic neurons from different ganglia innervating cardiac and vasculature tissue can also directly sense extracellular Na⁺. Using whole-cell patch clamp recordings we demonstrate that sympathetic neurons from three sympathetic ganglia (superior cervical, stellate and superior mesenteric/coeliac) respond to elevated extracellular NaCl concentration. In sympathetic stellate

SUBMITTER: Davis H 

PROVIDER: S-EPMC9247455 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature