Brain network hierarchy reorganization in Alzheimer's disease: A resting-state functional magnetic resonance imaging study.

ABSTRACT: Hierarchy is a fundamental organizational principle of the human brain network. Whether and how the network hierarchy changes in Alzheimer's disease (AD) remains unclear. To explore brain network hierarchy alterations in AD and their clinical relevance. Forty-nine healthy controls (HCs), 49 patients with mild cognitive impairment (MCI), and 49 patients with AD were included. The brain network hierarchy of each group was depicted by connectome gradient analyses. We assessed the network hierarchy changes by comparing the gradient values in each network across the AD, MCI, and HC groups. Whole-brain voxel-level gradient values were compared across the AD, MCI, and HC groups to identify abnormal brain regions. Finally, we examined the relationships between altered gradient values and clinical

SUBMITTER: Hu Q 

PROVIDER: S-EPMC9248302 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature