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Design, fabrication and testing of 3D printed smartphone-based device for collection of intrinsic fluorescence from human cervix.

ABSTRACT: Fluorescence spectroscopy has the potential to identify discriminatory signatures, crucial for early diagnosis of cervical cancer. We demonstrate here the design, fabrication and testing of a 3D printed smartphone based spectroscopic device. Polarized fluorescence and elastic scattering spectra are captured through the device using a 405 nm laser and a white LED source respectively. The device has been calibrated by comparison of spectra of standard fluorophores (Flavin adenine dinucleotide, fluorescein, rhodamine, and porphyrin) with the corresponding spectra collected from a commercial spectrometer. A few cervical tissue spectra have also been captured for proof of its applicability as a portable, standalone device for the collection of intrinsic fluorescence spectra from human cervix.

SUBMITTER: Shukla S

PROVIDER: S-EPMC9249735 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature

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Design, fabrication and testing of 3D printed smartphone-based device for collection of intrinsic fluorescence from human cervix.

Shukla Shivam S Sah Amar Nath AN Hatiboruah Diganta D Ahirwar Shikha S Nath Pabitra P Pradhan Asima A

Scientific reports 20220701 1

Fluorescence spectroscopy has the potential to identify discriminatory signatures, crucial for early diagnosis of cervical cancer. We demonstrate here the design, fabrication and testing of a 3D printed smartphone based spectroscopic device. Polarized fluorescence and elastic scattering spectra are captured through the device using a 405 nm laser and a white LED source respectively. The device has been calibrated by comparison of spectra of standard fluorophores (Flavin adenine dinucleotide, flu ...[more]

PMID: 35778460

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