Detection of volatile sulfur compounds (VSCs) in exhaled breath as a potential diagnostic method for oral squamous cell carcinoma.

ABSTRACT:

Background

Oral squamous cell carcinoma causes a significant proportion of global cancer morbidity and mortality. The aim of this study is to investigate whether the exhaled breath test can be a new, non-invasive, and effective method for diagnosing oral squamous cell carcinoma.

Methods

A comparative analysis of exhaled breath between patients with oral squamous cell carcinoma (OSCC) and healthy controls (HC) was performed with the Twin Breasor II™, a simple gas chromatography system.

Results

Both hydrogen sulfide (H₂S) and methyl mercaptan (Ch₃SH) were significantly higher in the OSCC group than in the HC group. The total sulfur concentration was also higher in the OSCC group, but there was no significant difference in the ratio of Ch₃

SUBMITTER: Kwon IJ 

PROVIDER: S-EPMC9250215 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature