Impact of interferon-induced transmembrane protein 3 gene rs12252 polymorphism on COVID-19 mortality.

ABSTRACT:

Background and aims

Interferon-induced transmembrane protein 3 (IFITM3) plays a critical role in the adaptive and innate immune response by preventing membrane hemifusion between the host and viral cell cytoplasm. This study aimed to evaluate whether IFITM3 rs12252 polymorphism is related to an increased mortality rate of coronavirus disease 2019 (COVID-19).

Methods

The IFITM3 rs12252 polymorphism was genotyped using the amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) in 548 dead and 630 improved patients positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

Results

In the present study, the minor allele frequency of IFITM3 rs12252 (C) was significantly more frequent in dead patients than in improved cases. The result

SUBMITTER: Ahmadi I 

PROVIDER: S-EPMC9250290 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature