Processing speed dysfunction is associated with functional corticostriatal circuit alterations in childhood epilepsy with centrotemporal spikes: a PET and fMRI study.

ABSTRACT:

Purpose

Epilepsy with centrotemporal spikes (ECTS) is the most common epilepsy syndrome in children and usually presents with cognitive dysfunctions. However, little is known about the processing speed dysfunction and the associated neuroimaging mechanism in ECTS. This study aims to investigate the brain functional abnormality of processing speed dysfunction in ECTS patients by using the ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography (PET) and resting-state functional magnetic resonance imaging (rs-fMRI).

Methods

This prospective study recruited twenty-eight ECTS patients who underwent the ¹⁸F-FDG PET, rs-fMRI, and neuropsychological examinations. Twenty children with extracranial tumors were included as PET controls, and 20 he

SUBMITTER: Li Y 

PROVIDER: S-EPMC9250469 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature