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Automated methodology for optimal selection of minimum electrode subsets for accurate EEG source estimation based on Genetic Algorithm optimization.

ABSTRACT: High-density Electroencephalography (HD-EEG) has proven to be the EEG montage that estimates the neural activity inside the brain with highest accuracy. Multiple studies have reported the effect of electrode number on source localization for specific sources and specific electrode configurations. The electrodes for these configurations are often manually selected to uniformly cover the entire head, going from 32 to 128 electrodes, but electrode configurations are not often selected according to their contribution to estimation accuracy. In this work, an optimization-based study is proposed to determine the minimum number of electrodes that can be used and to identify the optimal combinations of electrodes that can retain the localization accuracy of HD-EEG reconstructions. This optimization approach incorporates scalp landmark positions of widely used EEG montages. In this way, a systematic search for the minimum electrode subset is performed for single- and multiple-source localization problems. The Non-dominated Sorting Genetic Algorithm II (NSGA-II) combined with source reconstruction methods is used to formulate a multi-objective optimization problem that concurrently minimizes (1) the localization error for each source and (2) the number of required EEG electrodes. The method can be used for evaluating the source localization quality of low-density EEG systems (e.g. consumer-grade wearable EEG). We performed an evaluation over synthetic and real EEG datasets with known ground-truth. The experimental results show that optimal subsets with 6 electrodes can attain an equal or better accuracy than HD-EEG (with more than 200 channels) for a single source case. This happened when reconstructing a particular brain activity in more than 88% of the cases in synthetic signals and 63% in real signals, and in more than 88% and 73% of cases when considering optimal combinations with 8 channels. For a multiple-source case of three sources (only with synthetic signals), it was found that optimized combinations of 8, 12 and 16 electrodes attained an equal or better accuracy than HD-EEG with 231 electrodes in at least 58%, 76%, and 82% of cases respectively. Additionally, for such electrode numbers, lower mean errors and standard deviations than with 231 electrodes were obtained.

SUBMITTER: Soler A

PROVIDER: S-EPMC9250504 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Project description:Electroencephalography (EEG) and source estimation can be used to identify brain areas activated during a task, which could offer greater insight on cortical dynamics. Source estimation requires knowledge of the locations of the EEG electrodes. This could be provided with a template or obtained by digitizing the EEG electrode locations. Operator skill and inherent uncertainties of a digitizing system likely produce a range of digitization reliabilities, which could affect source estimation and the interpretation of the estimated source locations. Here, we compared the reliabilities of five digitizing methods (ultrasound, structured-light 3D scan, infrared 3D scan, motion capture probe, and motion capture) and determined the relationship between digitization reliability and source estimation uncertainty, assuming other contributors to source estimation uncertainty were constant. We digitized a mannequin head using each method five times and quantified the reliability and validity of each method. We created five hundred sets of electrode locations based on our reliability results and applied a dipole fitting algorithm (DIPFIT) to perform source estimation. The motion capture method, which recorded the locations of markers placed directly on the electrodes had the best reliability with an average electrode variability of 0.001 cm. Then, in order of decreasing reliability were the method using a digitizing probe in the motion capture system, an infrared 3D scanner, a structured-light 3D scanner, and an ultrasound digitization system. Unsurprisingly, uncertainty of the estimated source locations increased with greater variability of EEG electrode locations and less reliable digitizing systems. If EEG electrode location variability was ∽1 cm, a single source could shift by as much as 2 cm. To help translate these distances into practical terms, we quantified Brodmann area accuracy for each digitizing method and found that the average Brodmann area accuracy for all digitizing methods was >80%. Using a template of electrode locations reduced the Brodmann area accuracy to ∽50%. Overall, more reliable digitizing methods can reduce source estimation uncertainty, but the significance of the source estimation uncertainty depends on the desired spatial resolution. For accurate Brodmann area identification, any of the digitizing methods tested can be used confidently.

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Automated methodology for optimal selection of minimum electrode subsets for accurate EEG source estimation based on Genetic Algorithm optimization.

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