An integrated biomarker of PD-L1 expression and intraepithelial CD8⁺ T cell infiltration was associated with the prognosis of lung cancer patients after intracranial resection of brain metastases.

ABSTRACT:

Background

Brain metastases (BM) are common in lung cancer. However, data on the status of immune biomarkers in BM lesions remain limited.

Methods

We retrospectively analyzed PD-L1 expression and infiltration levels of CD3⁺ , CD4⁺ , CD8⁺ T cells as biomarkers by immunohistochemistry in both BM lesions and primary lung cancer (PL) lesions of 29 lung cancer (LC) patients. In addition, the correlations between these biomarkers and the clinical outcome were analyzed using log-rank test.

Results

Intratumoral heterogeneous expression of PD-L1 was observed on tumor cells (TCs) in 11 cases and on immune cells (ICs) in 10 cases with BM samples from multiple regions. There was a disagreement in PD-L1 expression on TCs between paired BM and PL le

SUBMITTER: Li LL 

PROVIDER: S-EPMC9250837 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature