Oral Anticoagulation Timing in Patients with Acute Ischemic Stroke and Atrial Fibrillation.

ABSTRACT:

Background and purpose

Oral anticoagulants (OACs) prevent stroke recurrence and vascular embolism in patients with acute ischemic stroke (AIS) and atrial fibrillation (AF). Based on empirical consensus, current guidance recommends a "1-3-6-12 days" rule to resume OACs after AIS. This study investigated the suitability of guideline-recommended timing for OAC initiation.

Methods

Using data of 12,307 AF patients hospitalized for AIS, for the period 2012 to 2016, in Taiwan's National Health Insurance Research Database, we constructed a sequence of cohorts of OAC users and propensity score-matched nonusers, creating one cohort on each day of OAC initiation for 30 days since admission. Composite outcome included effectiveness (cardiovascular death, ischemic stroke, myocardial infa

SUBMITTER: Chang PY 

PROVIDER: S-EPMC9251709 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature