High Blood Pressure and Intraocular Pressure: A Mendelian Randomization Study.

ABSTRACT:

Purpose

To test for causality with regard to the association between blood pressure (BP) and intraocular pressure (IOP) and glaucoma.

Methods

Single nucleotide polymorphisms (SNPs) associated with BP were identified in a genome-wide association study (GWAS) meta-analysis of 526,001 participants of European ancestry. These SNPs were used to assess the BP versus IOP relationship in a distinct sample (n = 70,832) whose corneal-compensated IOP (IOPcc) was measured. To evaluate the BP versus primary open-angle glaucoma (POAG) relationship, additional Mendelian randomization (MR) analyses were conducted using published GWAS summary statistics.

Results

Observational analysis revealed a linear relationship between BP traits and IOPcc, with a +0.28 mm Hg increase in IOPcc per

SUBMITTER: Plotnikov D 

PROVIDER: S-EPMC9251815 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature