Ontology highlight
ABSTRACT:
SUBMITTER: Lan TY
PROVIDER: S-EPMC9252301 | biostudies-literature | 2022 Jul
REPOSITORIES: biostudies-literature
Lan Ti Yen TY Boumal Nicolas N Singer Amit A
Acta crystallographica. Section A, Foundations and advances 20220624 Pt 4
A method is proposed to reconstruct the 3D molecular structure from micrographs collected at just one sample tilt angle in the random conical tilt scheme in cryo-electron microscopy. The method uses autocorrelation analysis on the micrographs to estimate features of the molecule which are invariant under certain nuisance parameters such as the positions of molecular projections in the micrographs. This enables the molecular structure to be reconstructed directly from micrographs, completely circ ...[more]